Roxithromycin is a semi synthetic antibiotic. It is used to treat bacterial infections. It can be used to treat certain infections of chest, tonsillitis, skin and genitals. It mainly works by inhibiting the growth of bacteria.

Indications:
● Tonsillitis Sinusitis
● Acute Bronchitis
● Skin or soft tissue infections
● Acute pharyngitis

Mechanism of Action:
Roxithromycin binds to 50 ribosomal subunits and inhibits the synthesis of the proteins in bacteria thus they do not receive adequate amount of nutrient and die.

Pharmacokinetics:
Absorption: It is absorbed orally
Protein Binding: It is bound mainly to alpha 1 acid glycoprotein
Metabolism: It is metabolized to N-dimethyl roxithromycin
Elimination:It is excreted via urine and feces

Interactions:
● Carbamazepine
● Ranitidine
● Antacids
● Prednisolone
● Contraceptives

Side Effects:
● Nausea
● Vomiting
● Diarrhoea
● Stomach-ache
● Flatulence
● Reddish skin

Contraindications:
● Contraindicated in known hypersensitivity
● Contraindicated in hepatic impairment

Caution:
Keep it reach out of children.